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多數(shù)與年齡相關的皮膚變化是光老化。一直以來，蝦青素這種高效抗氧化劑以及膠原蛋白水解物都被用作皮膚光老化的抗老化劑。然而，臨床中并沒有研究蝦青素和膠原蛋白水解物共同作用的結果。我們研究了膳食中補充蝦青素及膠原蛋白水解物對人體皮膚光老化的調節(jié)作用。44名健康的受試者在為期12周的時間內補充相同外觀和味道的蝦青素（2毫克/天）結合膠原水解物（3克/天）復合物或者安慰劑，然后利用不損傷皮膚的設備測定了面部皮膚的彈性及保濕性。此外，我們還研究了在受試前后膠原蛋白I、原纖蛋白-1、基質金屬蛋白酶-1和-12以及人工紫外誘導的臀部皮膚DNA損傷的變化。12周后發(fā)現(xiàn)與安慰劑組相比較，膳食補充蝦青素及膠原蛋白水解物可以顯著提高面部光老化皮膚的彈性和保濕性，提高膠原蛋白I mRNA的表達，降低基質金屬蛋白酶-1和-12的表達。但是，對于修復紫外誘導的DNA損傷，二者之間效果相差不大。這些結果表明膳食補充蝦青素及膠原蛋白水解物能夠提高光老化面部皮膚的彈性和完整性，這種治療方式也是可行的。

Supplementating with dietary astaxanthin combined with collagen hydrolysate improves facial elasticity and decreases matrix metalloproteinase-1and-12 expression: a comparative study with placebo.

Photoaging accounts for most age-related changes in skin appearance. It has been suggested that both astaxanthin, a potent antioxidant, and collagen hydrolysate can be used as antiaging modalities in photoaged skin. However, there is no clinical study using astaxanthin combined with collagen hydrolysate. We investigated the effects of using a combination of dietary astaxanthin and collagen hydrolysate supplementation on moderately photoaged skin in humans. A total of 44 healthy subjects were recruited and treated with astaxanthin (2 mg/day) combined with collagen hydrolysate (3 g/day) or placebos, which were identical in appearance and taste to the active supplementation for 12 weeks. The elasticity and hydration properties of facial skin were evaluated using noninvasive objective devices. In addition, we also evaluated the expression of procollagen type I, fibrillin-1, matrix metalloproteinase-1 (MMP-1) and -12, and ultraviolet (UV)-induced DNA damage in artificially UV-irradiated buttock skin before and after treatment. The supplement group showed significant improvements in skin elasticity and transepidermal water loss in photoaged facial skin after 12 weeks compared with the placebo group. In the supplement group, expression of procollagen type I mRNA increased and expression of MMP-1 and -12 mRNA decreased compared with those in the placebo group. In contrast, there was no significant difference in UV-induced DNA damage between groups. These results demonstrate that dietary astaxanthin combined with collagen hydrolysate can improve elasticity and barrier integrity in photoaged human facial skin, and such treatment is well tolerated.

Journal Of Medicinal Food. 2014,17(7):810-816.

Yoon HS, Cho HH, Cho S, Lee SR, Shin MH, Chung JH.